3-photon imaging of mouse brain activity is published in Nature Methods

3-photon imaging of mouse brain activity is published in Nature Methods


Dimitre G Ouzounov, Tianyu Wang, et al.  record spontaneous activity from up to 150 neurons in the hippocampal stratum pyramidale at ~1-mm depth within an intact mouse brain.

Using three-photon microscopy at 1,300-nm excitation, the authors of a recently published Nature Methods paper, demonstrated that functional imaging of GCaMP6s-labeled neurons can be achieved beyond the depth of two-photon microscopy. The method creates opportunities for noninvasive recording of neuronal activity with high spatial and temporal resolution deep within scattering brain tissues.

More on the lab

Nature Methods Paper – pdf



Neurotech symposium on the brain spotlights new discoveries

Researchers plumbing the mysteries of the brain gathered to share their discoveries at the inaugural Cornell Neurotech Mong Family Foundation Symposium, Sept. 29 in the Biotechnology Building.

The daylong symposium featured three of the winners of the prestigious Brain Prize – Winfried Denk, Ph.D. ’89; Karel Svoboda ’88; and David Tank, M.S. ’80, Ph.D. ’83 – all graduates of Professor Emeritus Watt Webb’s applied physics laboratory. The three built on their work in the Webb lab to develop multiphoton microscopy as an essential tool in brain research, allowing observation of minute brain structures and dynamic brain functions in real time.

Provost Michael Kotlikoff began the day with thanks for the “extraordinary generosity” of the Mong Family Foundation, guided by Stephen Mong ’92, M.Eng. ’93, MBA ’02, which enabled the university to launch Cornell Neurotech and sponsored the symposium. Cornell Neurotech’s efforts to understand how the brain produces behavior, thoughts and feelings “are vital goals with life-changing implications, and I am grateful to Stephen Mong and the Mong Family Foundation for enabling Cornell faculty and staff to strive toward them,” Kotlikoff said.

Read More

Early career scientists named as inaugural Mong Fellows in Neurotech

The inaugural Mong Family Foundation Fellows in Neurotech were named on June 17 and went to three pairs of early career scientists. They will work jointly under the mentorship of faculty across Cornell to advance technologies that promise to provide insight into how brains work, as well as strategies to fix them when they break. Read more…

Melissa Warden and Jesse Goldberg awarded New Innovator Awards

Neurotech Advisory Board members Melissa Warden and Jesse Goldberg were each awarded New Innovator Awards from the National Institute of Health. The new innovator award is one of the hardest to receive from the NIH and is designed to “support exceptionally creative, early-career investigators who propose innovative, high-impact projects.”